Stem cell transplants have been used since the 1960’s to treat a variety of diseases. In 1988 cord blood stem cells were used for the first time in hematopoietic (blood) stem cell transplantation. Umbilical cord blood stem cells have now been used in more than 15,000 transplants, through 2009, worldwide as a valuable alternative to traditional sources of hematopoietic stem cells. Utilizing the process of stem cell banking, cord blood stem cells also show great promise for potential future applications including treatment and repair of non-hematopoietic tissues, gene therapies, mini-transplants, among others.

Current Stem Cell Applications

Acute Leukemia’s

  • Acute Lymphoblast Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)
  • Acute Biphenotypic Leukemia
  • Acute Undifferentiated Leukemia

Chronic Leukemia’s

  • Chronic Myelogenous Leukemia (CML)
  • Chronic Lymphocytic Leukemia (CLL)
  • Juvenile Chronic Myelogenous Leukemia (JCML)
  • Juvenile Myelomonocytic Leukemia (JMML)

Myelodysplastic Syndromes

  • Refractory Anemia (RA)
  • Refractory Anemia with Ringed Sideroblasts (RARS)
  • Refractory Anemia with Excess Blasts (RAEB)
  • Refractory Anemia with Excess Blasts in Transformation (RAEB-T)
  • Chronic Myelomonocytic Leukemia (CMML)

Stem Cell Disorders

  • Aplastic Anemia (Severe)
  • Fanconi Anemia
  • Paroxysmal Nocturnal Hemoglobinuria (PNH)
  • Pure Red Cell Aplasia

Myeloproliferative Disorders

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia (myelofibrosis)
  • Polycythemia Vera
  • Essential Thrombocythemia

Phagocyte Disorders

  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Neutrophil Actin Deficiency
  • Reticular Dysgenesis

Other Inherited Disorders

  • Lesch-Nyhan Syndrome
  • Cartilage-Hair Hypoplasia
  • Glanzmann Thrombasthenia
  • Osteopetrosis
  • Adrenoleukodystrophy

Other Malignancies

  • Ewing Sarcoma
  • Neuroblastoma
  • Renal Cell Carcinoma
  • Retinoblastoma

Inherited Platelet Abnormalities

  • Amegakaryocytosis / Congenital Thrombocytopenia

Inherited Metabolic Disorders

  • Mucopolysaccharidoses (MPS)
  • Hurler’s Syndrome (MPS-IH)
  • Scheie Syndrome (MPS-IS)
  • Hunter’s Syndrome (MPS-II)
  • Sanfilippo Syndrome (MPS-III)
  • Morquio Syndrome (MPS-IV)
  • Maroteaux-Lamy Syndrome (MPS-VI)
  • Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
  • Adrenoleukodystrophy
  • Mucolipidosis II (I-cell Disease)
  • Krabbe Disease
  • Gaucher’s Disease
  • Niemann-Pick Disease
  • Wolman Disease
  • Metachromatic Leukodystrophy

Histiocytic Disorders

  • Familial Erythrophagocytic Lymphohistiocytosis
  • Histiocytosis-X
  • Hemophagocytosis

Inherited Erythrocyte Abnormalities

  • Beta Thalassemia Major
  • Sickle Cell Disease

Inherited Immune System Disorders

  • Ataxia-Telangiectasia
  • Kostmann Syndrome
  • Leukocyte Adhesion Deficiency
  • DiGeorge Syndrome
  • Bare Lymphocyte Syndrome
  • Omenn’s Syndrome
  • Severe Combined Immunodeficiency (SCID)
  • SCID with Adenosine Deaminase Deficiency
  • Absence of T & B Cells SCID
  • Absence of T Cells, Normal B Cell SCID
  • Common Variable Immunodeficiency
  • Wiskott-Aldrich Syndrome
  • X-Linked Lymphoproliferative Disorder

Plasma Cell Disorders

  • Multiple Myeloma
  • Plasma Cell Leukemia
  • Waldenstrom’s Macroglobulinemia
  • Amyloidosis

Lymphoproliferative Disorders

  • Non-Hodgkin’s Lymphoma
  • Hodgkin’s Disease

Potential Future Applications

  • Alzheimer’s Disease
  • ALS/Lou Gehrig’s Disease
  • Cardiac Disease
  • Cerebral Palsy
  • Diabetes
  • Epidermolysis Bullosa (rare genetic skin disease)
  • Huntington’s Disease
  • Lupus
  • Multiple Sclerosis
  • Muscular Dystrophy
  • Parkinson’s Disease
  • Rheumatoid Arthritis
  • Spinal Cord Injury
  • Stroke

Other cord blood banks may include diseases such as breast cancer and testicular cancer. CorCell has chosen not to include these diseases as clinical data has demonstrated that these diseases are not effectively treated with stem cell transplantation.This list represents major categories of diseases treated with stem cells and is not exhaustive. For instance, there are more than twenty (20) specific types of Non-Hodgkin’s Lymphoma and numerous types of Chronic Lymphocytic Leukemia, to name just two among many others.

References include:

  • National Marrow Donor Program ( Accessed 11-18-2003
  • Cord Blood and Our Tomorrow, Larry Lasky, MD. March/April 2001 American Association of Blood Banks
  • Tissue Engineering with Bone Marrow and Cord Blood Grows Heart Parts. American Heart Association – Top 10 Research Advances for 2001
  • Impact of Bone Marrow Transplantation on Type 1 diabetes. World Journal of surgery – Vol. 25, No.4. April 2001
  • Dystrophin Expression in the mdx Mouse Restored by Stem Cell Transplantation. Nature – Vol. 401. September 23, 1999